The 5 Best Nebulizers - [Updated for 2021]

For a person with a respiratory illness, a nebulizer is used to turn liquid medicine into a fine mist that is inhaled through a mask or mouthpiece, quickly delivering medication straight to the lungs.

These medications could be bronchodilators to open airways for easier breathing, sterile saline solution to open airways and thin mucus secretions, or antibiotics for someone with a severe infection.

A doctor will prescribe a nebulizer to treat asthma, chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis, and sometimes bronchitis or other respiratory infection. 

The Top 5:

Flyp Portable Handheld Nebulizer5) Flyp Portable Handheld Nebulizer

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Drive Medical PulmoMate Compressor Nebulizer System4) Drive Medical PulmoMate Compressor Nebulizer System

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nebGo Ultrasonic Travel Nebulizer System3) nebGo Ultrasonic Travel Nebulizer System

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PARI TREK S Compact Nebulizer Compressor Combination Pack2) PARI TREK S Compact Nebulizer Compressor Combination Pack

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Intelligent Mesh Handheld Portable Nebulizer by Briutcare1) Intelligent Mesh Handheld Portable Nebulizer by Briutcare

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#5 Portable Handheld Nebulizer


The #5 entry on our list is the lightweight Portable Handheld Nebulizer by Flyp Nebulizer. It will fit in your pocket and has no tubes, masks, or filters, delivering most treatments in about 7 minutes.

This ultrasonic portable nebulizer uses HypersoniQ technology to propel medicine from the 6 ml reservoir through holes in the vibrating disc, turning the liquid into an inhalable aerosol that is breathed in through an attachable mouthpiece. The nebulizer is smaller than a cellphone, and the “fill, click, breathe” operation makes this extremely convenient for on-the-go use.

It has a rechargeable lithium-ion battery that can go 15 treatments between charges via a USB charger. It also features a pulse cleaning mode that makes it easy to clean, especially if you have more than one kind of medicine.

If portability is a consideration, this nebulizer will allow you to inconspicuously take your treatment along with you wherever you go. It will conveniently, quietly, and quickly deliver medication without being encumbered by tubes, filters, and facemasks. 

Features and Benefits

  • Silent ultrasonic operation
  • No tubes or filters needed
  • Small and lightweight
  • Battery operated with USB dual voltage wall charger
  • Short treatment delivery time

Customer Feedback


  • Great asthma machine for easy convenient treatment
  • Can sleep with it close by to quickly treat nighttime COPD episodes
  • Fits conveniently in a purse to take along anywhere
  • Very inconspicuous so no one has to know you have a respiratory illness


  • You have to exhale to the side
  • Very different from the old nebulizer so it took some getting used to

#4 PulmoMate Compressor Nebulizer System


Our #4 choice for best nebulizers is the small and durable PulmoMate Compressor Nebulizer System by Drive Medical

This nebulizer can be angled up to 45 degrees to ensure the most comfortable treatment. It’s easy to take along on a trip, with a storage compartment for attachments and a sleek design to fit easily into a travel bag. 

It has a high-capacity medicine bowl that can deliver almost 20 percent more medication, and it seals securely to prevent spills. It can be cleaned in the dishwasher and its universal connector fits masks of all sizes, including a pediatric pacifier mouthpiece. This system comes with 7 inches of kink-resistant tubing and includes a VixOne disposable nebulizer. 

If you want a nebulizer that is convenient to take anywhere, easy to keep clean, and durable enough to count on for years to come, this system is a great choice. The manufacturer builds this nebulizer to last and backs it with a 5-year limited warranty.

Features and Benefits

  • Built-in storage compartment
  • Large capacity medication reservoir
  • Integrated handle for easy transport
  • Designed for years of service
  • Uses latest compressor technology
  • Uses latest robust quality and durability

Customer Feedback


  • Comes with a disposable nebulizer
  • One of the easiest asthma nebulizers to travel with
  • Connector works with pacifier attachment to treat babies
  • Choice of angle for most comfortable treatment
  • Good value for an asthma nebulizer


  • Being battery operated would make it even more attractive for travel
  • It weighs more than 5 pounds, so adds a lot of weight to a suitcase

#3 nebGo Ultrasonic Travel Nebulizer System


The nebGo Ultrasonic Travel Nebulizer System from Roscoe Medical is designed to meet on-the-go respiratory illness treatment needs and has earned the #3 spot on our list.

Its quiet operation and compact design means you can discreetly take your treatment wherever you need to. It comes complete with a long list of accessories, including a lanyard, medication cup, adult mask, child’s mask, mouthpiece, and USB cord and power plug. It also works on battery power, requiring only two easy-to-find AA batteries.

Even with the batteries, it weighs less than 4 ounces, so it’s easy to carry on the lanyard or in a pocket. It also has a hard-shell carrying case to keep it protected between treatments. It has the capacity to hold 6 ml of liquid medication, and its operating cycle is 20 minutes on and 20 minutes off. It uses vibrating mesh technology to deliver medicine whenever and wherever it’s needed.

An extremely portable model that can even be worn around your neck on its lanyard for quick access, this lightweight nebulizer is user-friendly and will suit you well if you want to be able to take a treatment anywhere at any time. 

Features and Benefits

  • Comes with adult and pediatric-sized masks
  • Uses ultrasonic technology to effectively deliver aerosolized medicine
  • Compact lightweight design makes it super portable
  • Delivers very precise treatment
  • User friendly and very easy to operate

Customer Feedback


  • Security when wearing it on a lanyard and knowing it’s close if needed
  • Very easy to use 
  • Uses common sized batteries
  • Great asthma machine for kids


  • Not the biggest medication bowl
  • Not a lot of leeway in treatment duration

#2 PARI TREK S Compact Nebulizer Compressor Combination Pack


The innovative portable PARI TREK S Compact Nebulizer Compressor Combination Pack from Independence Medical has been picked as our #2 entry. It delivers faster treatment from a small lightweight nebulizer so you can benefit from a treatment wherever you are.

With three power options of universal AC 100 to 240V, 12-volt car adapter, or battery power, you can take your treatment anywhere, including in the car. The rechargeable battery has a 50-minute charge and can be recharged within 2 hours. Weighing less than a pound, and less than 2 pounds with the battery, the compressor comes with 2 reusable nebulizers and can deliver a treatment in as few as 5 minutes. 

Although designed for portability, the compressor packs a lot into its compact design. It delivers the power of a tabletop model in the design of a portable unit, bringing together the best each of these designs has to offer.

If a powerful nebulizer that can deliver treatments quickly from pretty much anywhere is what you’re seeking, this combination pack will keep your treatment close at hand no matter where you are. Being able to charge it in the car makes it especially appealing if you spend a lot of time on the road. Its fast treatment time means you can address your respiratory illness efficiently no matter where you are, allowing you to quickly get back to your daily activities.

Features and Benefits

  • Multiple power source options
  • As powerful as much bigger units
  • Efficiently delivers on-the-go aerosol treatments
  • Treatment times as low as 5 minutes
  • Lightweight for easy transport

Customer Feedback


  • Size is great to take along while traveling
  • Big bonus to be able to charge on long car trips
  • Short treatment times
  • Just as comfortable using at home as a tabletop model


  • A bit louder than I expected
  • I have to use 2 vials at a time in my asthma machine and am afraid it will eventually overheat

#1 Intelligent Mesh Handheld Portable Nebulizer


Using the latest technology and claiming the top spot on our list with its smartphone app and interactive games is the Intelligent Mesh Handheld Portable Nebulizer from Briutcare

Adults like being able to transport this cell-phone-sized nebulizer in a purse or bag in a carry case that keeps all components protected and they appreciate the quiet operation that doesn’t disturb others no matter where you take your treatment. Kids like the choice of pink, gray, or green colors, and the interactive smartphone games that encourage compliance during a breathing treatment. In addition to fun games for kids, the app can adjust the nebulization rates to suit individual treatment needs.

With patented vibration mesh technology, medication reaches the lower respiratory tract, making breathing treatments shorter and more effective. The cough feeling is eliminated since the patented delivery system senses when you exhale and only delivers medicine when you inhale.

This handheld nebulizer made the top spot on our list because of its use of technology to personalize the treatment experience, and the adjustability the accompanying smartphone app provides. With benefits for kids and adults, this compact nebulizer doesn’t tie you to any one place for your treatment, makes the treatment quick and efficient, and makes the whole experience more enjoyable. For a powerful yet compact interactive unit, the Intelligent Mesh Handheld Portable Nebulizer stands out, delivering you a quick and comfortable treatment anywhere.

Features and Benefits

  • Rechargeable battery and automatic shut off feature
  • Adjustable nebulization rate
  • Compact and lightweight with a carry case to take along anywhere
  • Accompanying smartphone app
  • Senses breathing to deliver medicine only on inhalation

Customer Feedback


  • Reliable even when put to heavy use
  • Charges quickly
  • Perfect size to easily carry in a purse
  • Best asthma machine ever used


  • Can’t use hypertonic saline solution or other medications designed to be used with specific delivery devices
  • App is finicky and doesn’t always connect 

Things to Consider When Purchasing a Nebulizer

When choosing the right nebulizer, there are several factors to keep in mind while deciding which is the best option for your treatment needs.

Who Will Be Using It

If the nebulizer is for a child, there are pediatric models designed to fit smaller patients and be more attractive and engaging to kids through the use of colorful equipment or child-friendly themes.

Where It Will Be Used

Tabletop models are for indoor use on stable surfaces, and they often require close proximity to an electrical outlet for power. Lightweight handheld models allow for more mobility and usually have batteries so they are not tethered to an electrical outlet. Asthma patients who might need frequent treatments often benefit from smaller portable models that can be easily taken along anywhere.

Accessories and Compatibility

There are a lot of nebulizer accessories on the market, so it’s important to determine if your nebulizer will be a good fit for additional parts you might need.

Storage and Cleaning

Be sure the nebulizer is easy for you to clean and reset, and that you understand how to store it correctly. 

System Design

Tabletop System - For indoor use, it’s placed on a sturdy surface and is suitable for children who need a stationary unit. A tabletop unit is usually less expensive than a handheld model.

Handheld System - Providing the user with more mobility, small and lightweight handheld models usually have batteries.

Method of Nebulization

Jet/Aerosol (Piston Pump Compressor)

A piston-powered compressor forces air through the liquid medication using tubing and a nebulizer cup, creating a breathable mist. They are less expensive than ultrasonic nebulizers.


An ultrasonic model uses high frequency sound vibrations to turn liquid medication into an aerosol mist with particles that are smaller and more uniform in size than piston pump models create. They are usually quieter and deliver the medicine more quickly than other models.

Vibrating Mesh

This design has a screen with laser-drilled holes. The screen is placed across the medicine reservoir, creating a cool mist to be inhaled. It is an efficient delivery system without the waste seen in atomizer models.


Who needs a nebulizer?

Nebulizers are usually prescribed by doctors to treat asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, bronchiectasis, and sometimes respiratory infections like bronchitis.

What does a nebulizer do for your lungs?

A nebulizer can deliver life-saving medications when it is hard to breathe in. It turns liquid medications into a breathable mist, delivering it via mouthpiece or facemask. Pediatric nebulizers are also a good choice for children who may not be able to work an inhaler.

Is a nebulizer better than an inhaler?

Not better, but definitely different. An inhaler requires you to squeeze the device and inhale deeply at the right moment, a nebulizer automatically turns your medication into an aerosol for ingestion through breathing.

How do you use a nebulizer machine?

The basic steps to set up and use a nebulizer are:

  • Wash your hands 
  • Connect hose to air compressor
  • Fill medicine reservoir
  • Attach hose and mouthpiece to medicine cup
  • Place mouthpiece in your mouth with lips firm around it
  • Breathe through mouth until all the medicine is gone
  • Turn off machine
  • Wash the medical cup and mouthpiece 

What medication is used in a nebulizer for asthma?

Corticosteroids are used to open constricted airways. Examples of these medicines are Albuteral, Xopenex, and Pulmicort.


No matter what features you’re looking for or what kind of nebulizer will work best for you, you’ll find a model on our top 5 list that will effectively deliver treatment and relief. Our #1 choice is the Intelligent Mesh Handheld Portable Nebulizer. If you haven't found what you are looking for, then we encourage you to browse our entire selection of full list of nebulizers

Be sure to check out our free blog, Caregiver University, for more informative articles!


Co-Founder of Rehabmart and an Occupational Therapist since 1993. Mike has spent his professional career working in multiple areas of Occupational Therapy, including pediatrics, geriatrics, hand therapy, ergonomics and inpatient / outpatient rehabilitation. Mike enjoys writing articles that help people solve complex therapeutic problems and make better product choices.

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